乳酸司氟沙星葡萄糖注射液治疗细菌性感染的临床疗效观察

A Randomized Controlled Clinical Trial of Sparfloxacin Versus Ofloxacin in the Treatment of Bacterial Infections

目的 评价乳酸司氟沙星葡萄糖注射液治疗细菌性感染的临床疗效。方法 4 1例病人 ,分为治疗组 2 1例和对照组2 0例 ,分别应用乳酸司氟沙星葡萄糖注射液和氧氟沙星注射液 ,剂量分别为 0 .2g,qd和 0 .2g ,q12h ,iv ,疗程 7～ 14d。结果 乳酸司氟沙星和氧氟沙星的临床有效率分别为 85 .71%和 85 .0 % ,细菌清除率分别为 72 .73%和 77.78% ,两组不良反应发生率分别为 9.5 2 %和 5 .0 % ,试验中未见光敏反应及其他严重不良反应。结论 乳酸司氟沙星葡萄糖注射液可作为治疗细菌性感染有效。

Aim To evaluate the efficacy and safety of sparfloxacin in the treatment of bacterial infections.Methods A randomized controlled clinical trial was conducted.Ofloxacin was used as the control drug.Dosage:sparfloxacin,0.2g,intravenous infusion,once daily;ofloxacin,0.2g,intravenous infusion,q12h.The duration of treatment was 7～14 days.Results The overall efficacy rates of sparfloxacin and ofloxacin were 85.71% and 85.0% respectively.The bacterical clearance rates were 72.73% in the sparfloxacin group and 77.78% in the ofloxacin group.There was no statistical significant difference between the two groups for the above results.The adverse reaction rates of sparfloxacin and ofloxacin were 9.52% and 5.0%,respectively.Conclusion Sparfloxacin is a highly effective and safe broad-spectrum antibacterial agent for the treatment of bacterial infections.