砷对细胞和生物作用的研究进展

Progress of Studies on Effects of Arsenic on Cells and Organisms

砷化物对于生物是有毒物质,可以导致细胞的染色体异常和基因突变。砷化物还可以改变某些基因的功能,诱导癌症的发生。生物接触砷化物后,细胞内一些基因表达发生了改变。研究表明原核生物及真核生物对砷化物的作用都产生了分子水平的应答。通过研究砷化物与基因相互作用的关系,对于揭示细胞和生物同砷化物的分子作用机制,阐明各种细胞和生物的抗砷分子机制有重要意义。另外,目前发现三氧化二砷能通过不同细胞信号传导途径诱导细胞凋亡。

Arsenic compounds are poisonous to organisms,which may induce chromosome aberration and gene mutation of cells.Arsenic compounds may also change the gene functions and cause carcinoma.After exposure to arsenic compounds,gene expressions in some cells were changed.The results of some molecular biology studies showed that both prokaryote and eukary-ote had responses to arsenic compounds at molecular levels.It will be important for unveiling the molecular mechanisms of ar-senic compoundseffects on cells and organisms and the arsenic-resistance of various cells and organism by studying the inter-actions between arsenic compounds and genes.In addition,it was recently found that arsenic trioxide could induce cell apoptosis by various cellular signal transduction pathways.