血友病甲患者Ⅷ因子检测及相关传染病调查

Quantitive Detection of Active Factor Ⅷ and Investigation of Infectious Disease Relating with Hematophilia

目的 建立血友病甲体内Ⅷ因子活性定量检测方法,了解我省血友病甲患者中相关传染病情况。方法 Ⅷ因子活性定量检测采用凝血因子Ⅷ促凝活性试验。HBsAg、抗-HCV、抗-HIV的检测采用ELISA法。结果 凝血因子Ⅷ促凝活性定量检测试验用于诊断血友病甲灵敏度高特异性好优于传统的筛查方法。血友病甲患者中抗-HCV、抗-HIV的感染率高于正常人群。结论 应进一步加强对血友病患者监督和管理。

Objective To establish method of quantitive detection if active factor Ⅷ and investigation of infectious disease relating with Hematophilia. Methods Detection active factorⅧ used method of factor Ⅷ assisting clot test. Detection HBsAg、anti - HCV antibody、 anti - HIV antibody used ELISA method. Results Factor Ⅷ assisting clot test is better than traditional screening test in sensitivity and specificity. HCV and HIV infectious rate is higher than normal person population. Conclusion It must be that we strengthen supervising and managing with Hematophilia.