过敏性紫癜患儿血流变学观察及临床意义

Oinical Significance of Hemorheology in Children with Henoch Schonlein Purpura

目的:探讨过敏性紫癜血流变学变化及其临床意义,方法:检测住院病人13例血流变学。结果:发现过敏性紫癜(HSP)组红细胞压积增高,血浆粘度和全血粘度显著增高,而纤维蛋白原和红细胞电泳均值虽高于对照组,但无统计学意义。结论:HSP时高红细胞压积,高血浆粘度和高全血粘度是促成高凝状态、易并发血栓形成的高危因素,同时血液粘滞度增高,血流缓慢,造成组织灌流不足,进一步加剧血管炎症反应和器官功能损伤,提示临床上应积极处理高粘滞血症,及时应用改善微循环的药物,对于减轻并发症,缩短病程和防止复发,有十分重要的作用。

Objective:To study the change of hemorheology in children with Henoch Schonlein purpura and its clinical significance. Methods: The hemorheology in 13 impatients with Henoch Schonlein purpura was checked up. Results: In 13 inpatients the packed cell voluml, the viscosities of blood plasma and whole blood were significantly elevated. The mean values of fibrinogen and ery-throcyte electrophoresis in them were higher than that in control group, but the variation was not significant. Conclusion: High packed-cell volume and hyperviscosities of blood plasma and whole blood are the main factors of impeh'ng the blood to be in a state of coagulation and developing thrombogenesis. Besides, hyperviscosity and slow stream of blood result in the hypoperfusion, which can aggravate inflammation response of blood vessels and functional disturbance of organs. It is suggested that the hyperviscosity of blood should be treated actively,the drugs which can improve microcirculation should be used in time.These measures and important to decrease the complications, shorten the course of disease and prevent the diseases from recurring.