蛋白激酶C阳性细胞在大鼠大脑皮质和海马结构的分布

The distribution of protein kinase C positive cells in the cerebral cortex and hippocampus formation of rats

目的:观察蛋白激酶C(PKC)阳性细胞在大鼠大脑皮质和海马结构的形态和分布,为更好地研究PKC在中枢神经系统的生理作用提供形态学的基础。方法:用免疫组织化学方法检测了大脑皮质和海马结构PKC阳性细胞的分布。结果:PKC阳性细胞胞体较小,多呈卵圆形,少数呈三角形,多数突起较短。PKC阳性细胞主要分布在大脑的额叶、顶叶、颞叶和枕叶的II、III和IV层,在杏仁海马移行区和杏仁梨状皮质移行区也有分布。海马结构中主要分布在下托和齿状回的颗粒层、海马CA1区的锥体层和辐射层。结论:在大脑皮质和海马结构有PKC阳性细胞的广泛分布。

Aim: To observe the form and distribution of protein kinase C (PKC)positive cells in the cerebral cortex and hippocampus formation of rats,It will provide a morphological base for further studying PKC physiological function in the central nervous system. Methods: The distribution of the PKC positive cells in the cerebral cortex and hippocampus formation was studied by immunnohistochemical method. Results: Most bodies of PKC positive cells are small and oval, minor are triangular,and the processes are short.The PKC positive cells were mainly distributed in the II,III and IV layers of the frontal lobe, parietal lobe, temporal lobe and occipital lobe of the cerebral cortex. Amygdalohippocampal transition area and amygdalopiriform transition area also are found, So are the granular layer of dentate gyrus and the subiculum, the pyramidal and radiation layers of the CA1 region in the hippocampus formation. Conclusion: PKC positive cells are widely distributed in the cerebral cortex and hippocampus formation. 