利培酮对慢性精神分裂症抑郁症状疗效的探讨

A study on the efficacy of risperidone in the treatment of chronic schizophrenia with depression

目的 :探讨利培酮治疗慢性精神分裂症患者抑郁症状的疗效。方法 :对符合ICD - 10、CCMD - 2 -R诊断标准的慢性精神分裂症。且PANSS评分 >6 0分。HAMD(17项 )评分 >16分共 5 4例长期住院患者进行了疗程为 12周的开放性研究。在治疗前及治疗后 2、4、6、8、12周分别用阳性与阴性症状量表 (PANSS)、汉密顿抑郁量表 (HAMD)评定疗效 ,副反应量表 (TESS)评定不良反应。结果 :利培酮对长期住院慢性精神分裂症的总有效率为70 37% ,对伴发的抑郁症状的总有效率为 74 0 7%。治疗前后PANSS总分及HAMD、总分均有显著差异 (P <0 0 5 )。常见副反应为锥体外系症状 ,程度较轻。结论 :利培酮是一种安全有效抗精神病药物 ,对慢性精神分裂症患者抑郁症状改善明显。

Objective:To explore the efficacy of risperidone in the treatment of chronic schizophrenia with depression.Methods:According to clinic diagnosis of ICD-10.CCMD-2-R and PANSS>60.LIAMD>16 opening treatments in 54 patients were carried out.The therapeletic and side effects were evaluated with PANSS,HAMD and TESS in 2,4,6,8,12weeks.Results:The overall therapeutic effects of ris peridone in the treatment of chronic schizophrenia and depression were 70.37%,74.07% respeatively.There were statistical differences in the PANSS total scores and HAMD( P <0.05).Few side effects were EPS.Condaston:Risperidone was very effective in the treatment of schizophrenia with depression.