病毒性肝炎患者血清一氧化氮水平的动态变化及其规律的临床研究

A clinical study on serum regular change of NO in virus hepatitis

目的 :研究病毒性肝炎患者血清一氧化氮 ( NO)水平的动态变化及其规律 ,探讨其临床诊断价值。方法 :对188例各型病毒性肝炎患者的血清 NO水平进行检测 ,分析其动态变化 ,并与生化指标和肝纤维化指标进行对照研究。结果 :各组肝炎患者血清 NO浓度均明显高于正常对照组 ,而且各组间比较有显著性差异 ( F=3.6 1,P<0 .0 1) ;在各型肝炎的病情活动期 ,血清 NO明显升高 ,而随着病情的逐渐恢复 ,血清 NO的浓度逐渐下降 ( P<0 .0 5或 <0 .0 1) ;在肝纤维化血清学标志物 HA、L N、IV- C和 PC 明显升高的患者中 ,其血清 NO含量也明显升高 ;在 AL T与 NO的关系中 ,急性肝炎患者呈极显著负相关 ( r=- 0 .92 17,P<0 .0 1) ,重型肝炎患者呈极显著正相关 ( r=0 .6 776 ,P<0 .0 1) ,慢性肝炎无明显相关性 ( r=0 .12 4 7,P>0 .0 5 )。在 TBil与血清 NO的关系中 ,急、慢性肝炎和重型肝炎患者无明显相关性 (分别为 r=- 0 .0 815、r=0 .2 5 5 3和 r=- 0 .345 2 ,P>0 .0 5 )。结论 :病毒性肝炎时血清 NO浓度的变化与肝内炎症程度、肝病严重程度及病程的演变方向密切相关 。

Objective:To study serum regular change of NO in virus hepatitis,investigate its diagnostic value.Methods:Serum No was detected in 118 cases of virus hepatitis,its regular change was analyzed and were compared with the biochemical criterion and hepatic fibrosis mark.Results:Serum concentration of NO was higher than the control group in virus hepatitis.There were significantly difference at several groups(F=3.61, P <0.01).Serum concentration of NO was higher in the active phase of illness.It was less after the convalescent periol of illness( P <0.05).Among the patients with raised of HA,LN,IV-C and PCⅢ,serum concentration of NO was higher.About the relation of ALT and No,there was a high negative correlation in the acute hepatitis(r=-0.9217, P <0.01).There was a significant relation in the severe hepatitis (r=0.6776, P <0.01).There was no relation in the chronic hepatitis(r=0.1247, P >0.05).About the relation of TBil and NO,there was no relation in the patients of acute hepatitis,chronic hepatitis and severe hepatitis(r=-0.0815,r=0.2553 and r=-0.3452, P >0.05).Conclusion:Serum regular change of NO was a significant relation with hepatic inflammation,severe degree of hepatitis and clinical development in virus hepatitis,and was a sensitive mark on hepatic fibrosis.