有无遗传史的强迫症患者心理及生物学指标比较研究

A Study of the Psychology and Biology Difference between Obsessive-Compulsive Disorder Patients with or without Inherited History

目的 :探讨强迫症的家族遗传倾向及生物和文化因素对其发病的作用。方法 :采用家族史法调查强迫症先证者家属中各种精神障碍的患病率 ,按家族史有无进行分组 ,并对患者进行量表评定 (生活事件量表、DSQ、MMPI、HAMD、HAMA)、脑SPECT检测以及血小板 5 -HT、血浆PRL与皮质醇水平的测定。结果 :强迫症患者 1/ 2具有阳性家族史 ,阳 /阴性家族史亚组间血 5 -HT、PRL、皮质醇水平均无显著性差异 ;阴性组采用中间型防御机制多于阳性组 (P <0 .0 5 )。结论 :强迫症为一种家族传递性疾病 ,家庭或社会文化环境对其发病可能有重要作用。

Objective:To explore the familial inheritance tendency of obsessive-compulsive disorder(OCD) and the role of biotic and social culture factor influence for the generation of the disorder. Methods: The prevalence rate of various mental disorders in the family members of OCD probands was investigated by means of family history. OCD probands were divided into two groups according to with or without family history of mental disorder and evaluated by Life Events Scales,DSQ, MMPI, HAMD,HAMA,and the blood serotonin, PRL and cortisol level of two groups were determined. Restults: Half of the OCD probands have positive family history.There was no significant difference in the level of blood serotonin, PRL and cortisol between the two subgroups.The negative family history subgroup more often use intermediate type of defense mechanisms than the positive subgroup( P <0.05).Conclusions: OCD is a kind of family transmit disorder, family or social culture environment may play a important role in the occurrence of OCD.