生长激素应用于全身炎症反应综合征时二胺氧化酶及内毒素变化的临床意义

Effect of Human Growth Hormone on Diamine Oxidase and Endotoxemia in Systemic Inflammatory Response Syndrome

目的 探讨生长激素应用于全身炎症反应综合征时二胺氧化酶 (DAO)和内毒素 (ET )水平的变化及其与肠粘膜屏障损伤的关系。方法 将 14 6例严重感染性疾病合并全身炎症反应综合征患者分为非手术组和手术组两组 ,再分别将此两组随机分为治疗组及对照组 ,于治疗前及治疗后 1周监测血浆DAO和ET水平。结果 治疗组血浆DAO及ET水平在治疗后较治疗前下降 ,且差异有显著性意义 (P<0 .0 5 ,P<0 .0 1)。结论 生长激素对严重感染性疾病合并全身炎症反应综合征患者的肠粘膜屏障具有一定的保护作用。

Objective To investigate the changes of diamine oxidase(DAO) and endotoxin(ET) during the treatment of systemic inflammatory response syndrome with human growth hormone and the relationship between human growth hormone and intestinal mucosal barrier injury. Methods One hundred and forty six patients with systemic inflammatory response syndrome were randomly divided into operative group and non operative group, which were again randomly divided into the study group and control group.Plasma concentration of DAO and ET were determined before the treatment and 1 week after the treatment.Results Plasma concentration of DAO and ET in study group decreased after treatment with significant difference ( P <0.05, P <0.01).Conclusion Human growth hormone can protect intestinal mucosa barrier.