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热休克蛋白对缺氧缺血性脑损伤神经元凋亡的保护作用及机制 被引量：2

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摘要 热休克蛋白(HSP)是机体在受到应激刺激后诱导产生的一组蛋白质,对细胞损伤具有保护作用。近年来较多文献报道HSP对缺氧缺血性脑损伤神经元的凋亡具有保护作用。本文就HSP的特点、脑缺氧缺血后神经元中HSP的表达及其对神经元凋亡的保护作用和机制进行综述。
作者 刘玲
机构地区 中南大学附属湘雅医院儿科
出处 《国外医学（儿科学分册）》 2003年第3期121-123,共3页 Foreign Medical Sciences（Section of Pediatrics)
关键词 缺氧缺血性脑损伤 神经元凋亡 热休克蛋白 线粒体 应激激活激酶途径 p53基因 BAX基因 BCL-2基因 核转录因子
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献23

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同被引文献16

  • 1尹晓娟,巨容,封志纯.建立新生鼠缺氧缺血性脑病模型的一种简单可靠的方法[J].实用儿科临床杂志,2005,20(8):744-746. 被引量：10
  • 2陈秀莲,孙林,于培兰,陈瑞.热休克蛋白70与缺血性脑损伤[J].中国临床康复,2006,10(24):137-139. 被引量：7
  • 3张费通,崔其亮,刘海燕,黎刚,谭岱峰.新生鼠缺氧缺血性脑病水通道蛋白4与肿瘤坏死因子-α的变化及意义[J].实用医学杂志,2007,23(3):339-341. 被引量：3
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  • 5Cheng EH, Wei MC, Weiler S,et al. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis[ J ]. Mol Cell,2001,8 ( 3 ) :705 - 711.
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  • 10Kinoshita Y,Ueyama T,Senba E.Expression of c-fos,heat shock protein 70,neurotrophins,and cyclooxygenase-2 mRNA in response to focal cerebral ischemia/reperfusion in rats and their modification by magnesium sulfate[J].J Neurotrauma,2001,18(4):435-445.

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国外医学（儿科学分册）
2003年 第3期

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