C-反应蛋白及食物中n-3脂肪酸与冠状动脉疾病的关系

Relation between coronary artery disease and C-reaction protein,dietary n-3 fatty acids

目的 研究急相C 反应蛋白 (CRP)及食物n 3脂肪酸 (FA)与冠状动脉疾病 (CAD)的关系。方法 对临床疑为CAD的 2 6 9例病人施行血管造影术 ;针对鱼类摄入量 ,所有病人都接受食物问卷调查 ;利用气相层析法测定粒细胞膜中n 3多价不饱和脂肪酸 (PUFA)的含量 ;利用比浊法测定血清CRP含量 ,研究海产品中n 3PUFA对CRP水平的影响。结果 血管造影术证实 72例病人有心肌梗塞 (MI)病史。冠状动脉直径狭窄 >5 0 %的支数 1支的有 6 5例 ,2支的有 4 6例 ,3支的有 77例。总体CRP均值 (x)为 2 .97± 2 .36mg/L。CRP水平与鱼类摄入量无关。冠状动脉狭窄病例血清CRP水平明显高于那些冠状动脉造影无明显改变的病例 (P =0 .0 0 1) ;CRP水平较低者粒细胞中廿二碳六烯酸 (DHA)含量明显高于CRP水平较高者 (P =0 .0 2 )。结论 CRP与海产品中n 3PUFA、DHA呈负相关 。

Objective To study on the relation between coronary artery disease (CAD) and C reaction protein(CRP),dietary n 3 fatty acids(FA). Methods Coronary artery angiography was performed in 269 patients that clinical suspicion of CAD.All patients filled out a food questionnaire regarding fish intake.The content of n 3 polyunsaturated fatty acids in granulocyte membranes was measured by gas chromatography.Determination of CRP was performed with nephelometric assay,and study the effect of marine n 3 PUFA on CRP levels.Results 72 patients were proved had a previous myocardial infarction (MI).The number of coronary arteries narrowed >50% as below:65 patients with 1 vessel,46 patients with 2 vessel,and 77patients with 3 vessel.The mean value of CRP in the population was 2.97±2.36mg/L.There was no relation between CRP and fish score.Serum levels of CRP were significantly higher in subjects with significant coronary arteries stenoses( P <0.001). Subjects with serum lower levels of CRP had significantly higher contents of docosahexaenoic acid(DHA) in granulocyte than subjects with serum upper levels of CRP( P =0.02). Conclusion The inverse correlation between CRP and marine n 3 PUFA and DHA,and suggest a novel mechanism by which fish consumption may decrease the risk of CAD.