紫杉类药物耐药的相关分子生物学指标
被引量:1
Assessment of molecular markers relating with resistance to taxanese
摘要
耐药是影响紫杉类药物临床疗效的重要因素。回顾与紫杉类耐药相关的分子生物学指标 ,并从多药耐药(MDR)机制、微管、凋亡因子、细胞周期蛋白监控、HER 2、BRCA 1、BRCA 2、紫杉醇耐药相关基因
出处
《国外医学(肿瘤学分册)》
2003年第2期95-98,共4页
Foreign Medical Sciences (Cancer Section)
参考文献20
-
1Ihnat MA, Nervi AM, Anthony SP et al. Effects of mitomycin C and carboplatin pretreatment on multidrug resistance-associated P-glycoprotein expression and on subsequent suppression of tumor growth by doxorubicin and paclitaxel in human metastatic breast cancer xenografted nude mice [J]. Oncol Res, 1999,11(7) : 303-310.
-
2Smith AJ, van Helvoort A, van Meer G, et al. MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping [J]. J Biol Chem, 2000, 275(31): 23530-23539.
-
3Scheffer GL, Schroeijers AB, Izquierdo MA, et al. Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer [J]. Curt Opin Oncol, 2000,12(6) : 550-556.
-
4Ding S, Chamberlain M, McLaren A, et al. Cross-talk between signaling pathways and the multidrug resistant protein MDR-1 [J]. Br J Cancer, 2001,85(8) : 1175-1184.
-
5Mu JH, Bollon AP, Sidhu RS. Analysis of beta-tubulin cDNAs from taxol-resistant Pestalotiopsis microspora and taxol-sensitive Pythium ultimum and comparison of the taxol-binding properties of their products[J]. Mol Gen Genet, 1999, 262(4-5) : 857-868.
-
6Kavallaris M, Burkhart CA, Horwitz SB. Antisense oligonucleotides to class Ⅲ beta-tubulin sensitize drug-resistant cells to Taxol [J]. Br J Cancer, 1999,80(7): 1020-1025.
-
7Kyu Ho Han E, Gehrke L, Tahir SK, et al. Modulation of drug resistance by alpha-tubulin in paclitaxel-resistant human lung cancer cell lines [J]. Eur J Cancer, 2000,36(12) : 1565-1571.
-
8Ferreira OG, Tolis C, Span SW, et al. Drug-induced apoptosis in lung cancer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway[J].Clin Cancer Res,2000,6(1):203-212.
-
9Pucci B, Bellincampi L, Tafani M, et al. Paclitaxel induces apoptosis in Saos-2 cells with CD95L upregulation and Bcl-2 phosphorylation[J]. Exp Cell Res, 1999, 252(1): 134-143.
-
10Cassinelli G, Supino R, Perego P, et al. A role for loss of p53 function in sensitivity of ovarian carcinoma cells to taxanes [J]. Int J Cancer, 2001,92(5): 738-747.
同被引文献9
-
1Szabo D, Keyzer H, Kaiser HE, et al. Reversal of multidrug resistance of tumor cells [J]. Anticancer Res, 2000, 20(6B):4261-4274.
-
2Cole SP , Bhardwaj G, Gerlach JH, et al. Over-expression of a transporter gene in a muhifrug-resistant human lung cancer cell line [J]. Science, 1992,258(5088):201650.
-
3Kabarakal L, Orker K, Haying! M, etal. Technetium-99m sestamibi uptake in human breast carcinoma cell lines displaying glutathione-associated drug-resistance[J]. Eur J Nucl Med, 1996,23(5):568-570.
-
4Kigawa J, Sato S, Shimada M, et al. p53 gene status and chemosensitivity in ovarian cancer[J]. Hum Cell, 2001,14(3):165-171.
-
5Funato T, Kozawa K, Kaku M, et al. Modification of the sensiticity to cisplatin with c-mye over-expression or down-regulation in colon cancer cells [J]. Anticancer Drugs,2001,12(10):829-834.
-
6Wartenberg M,Ling FCm Schallenberh M. et al. Down-regulation of intrinsic P-glycopmtein expression in mmulficellular prostate tumor spheroids b reactive oxygen species[J]. J Biol Chem, 2001,276(20):17420-17428.
-
7Gana Weisz M, Halaschek Wiener J, Jansen B, et al. The Ras inhibitor S-tmns, trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance [J].Chin Cancer Res, 2002,8(2):555-565.
-
8Swannie HC, Kaye SB. Protein kinase C inhibitors [J].Curr Oncol Rep, 2004(1):37-46.
-
9金澎,张庆林,刘福生,陶荣杰,魏林,王成伟,孔建新.MGMT反义RNA对人脑胶质瘤细胞系U251/BCNU耐药性逆转的研究[J].山东医药,2001,41(19):6-8. 被引量:2
-
1伍彬,杨宗发.紫杉类药物药理及临床研究进展[J].中国药业,2004,13(6):77-78. 被引量:10
-
2王玉涛,杨丽萍.草酸铂联合替吉奥治疗晚期胃癌的疗效观察[J].实用医技杂志,2011,18(11):1184-1185.
-
3刘姝.紫杉类药物对晚期乳腺癌患者的临床疗效评价[J].抗感染药学,2016,13(2):470-471. 被引量:1
-
4严婷婷(综述),林燕苹(综述),陆劲松(审校).紫杉类药物在乳腺癌治疗中的耐药机制[J].国际肿瘤学杂志,2009,36(10):780-782. 被引量:1
-
5冯刚,张湘茹.紫杉类药物治疗卵巢癌[J].中国新药杂志,1998,7(4):273-276. 被引量:22
-
6王粉侠.紫杉类药物腹腔灌注治疗晚期恶性肿瘤的安全性观察[J].中国药业,2015,24(B11):56-57.
-
7孙海,耿建,陈龙邦.紫杉类药物耐药机制的研究进展[J].医学研究生学报,2007,20(3):315-318. 被引量:11
-
8英国:“无癌婴儿”出生[J].医院管理论坛,2009,26(2):7-7.
-
9汪利珍,姚平芳,马娟.卵巢癌患者应用紫杉类药物发生过敏反应的护理40例[J].中国实用护理杂志(下旬版),2005,21(1):43-44. 被引量:9
-
10张苗苗,王兴元,邢镨元,冯奉仪.多西他赛联合奥沙利铂和5-氟尿嘧啶方案治疗晚期胃癌41例[J].中国新药杂志,2012,21(7):767-771. 被引量:5