涎腺腺样囊性癌DNA含量与临床及组织学类型间关系的研究

Study on the Correlation Among the Cellular DNA Content, Clinical Appearance and the Histopathologic Patterns of Salivary Adenoid Cystic Carcinoma

对29例涎腺腺样囊性癌(SACC)的病理分型及临床表现进行比较,应用多功能图像仪对上述SACC 的核内 DNA 含量进行了测量,并按病理分型进行了分析。结果表明:1.组织病理分型与临床表现间有明显的对应关系,实体型的临床表现最差,5年生存率56.68%±13.3%,筛状型的临床表现最佳,5年生存率为77.74%±6.78%。小条索小团块型术后复发率较高,5年生存率为72.53%±4.66%,2.29例 SACC 中26/29例的 DNA 含量在二倍体范围,3/29例为异倍体,并且 DNA 含量与组织病理分型间无明显对应关系。目前在分子水平上使 SACC 诊断定量化尚有困难。

The cellular DNA content of 29 cases of salivary adenoid cystic carcinoma (SACC)was quantified with image cytometric analysis.The comparasion and anal-ysis among the cellular DNA content,histopathologic and clinical appearance weredone:No significant correlation between the cellular DNA content and the histopathol-ogic patterns,the cellular DNA content and the clinical appearance was found,but aclose correlation was found between the histopathologic patterns and the clinical appe-arances of SACC.Majority of 29 cases(26/29)had normal DNA content,which sho-wed that it is difficult to quantify the-diagnosis of SACC at present.