下颌前伸后大鼠下颌髁突适应性生长改建的组织学和组织化学研究

Histologic and Histochemical Studies of Mandibular Condylar Adaptation after Mandibular Advancement in Young Growing Rat

应用上颌功能性活动矫治器,引导生长期大鼠下颌前伸,用组织学、粘液组织化学和酶组织化学方法,研究前仲后髁突软骨的组织结构、粘液成份和酶代谢的变化规律。结果显示髁突中、后份软骨生发层增厚,各种粘液物质增多,无氧酵解酶活动增高。表明功能矫形前伸生长期大鼠下颌骨,能刺激髁突中、后份软骨增生,下颌前伸后,髁突前份受压,缺血、缺氧、坏死,软骨被纤维组织取代,髁突发生适应性生长改建。

Removable functional appliance was used to induce the mandibular advancement inyoung rat.Histologic and histochemical methods were employed to investigate the condy-lar cartilage structure,mucosaosubstances and enzyme metabolism changes after the man-dibular functional protrusion.The results showed that the germinal layer of condylar ca-rtilage was thicker in experimental group than in control group in middle and posteriorregion.Mucosaosubstances and the enzyme activity of LDH and α-GPD were significantlyincreased.It is suggested that the condylar cartilage multiplication can be promoted afterthe mandibular functional protrusion in young growing rat.