摘要
沙培林(Sapylin)在临床上治疗口腔鳞癌具有一定效果。本文研究了 Sapylin 对舌鳞癌细胞株(Tca8113)细胞的抑制作用机理。实验证实:Sapylin 能抑制 Tca8113细胞的 DNA 合成;Sapylin 含量为0.015KE/ml~0.00375KE/ml,其抑制率为53.8%~61.3%。含量为1.0KE/ml时,培养8天后的Tca8113细胞集落形成率为0。提示 Sapylin 有抑制舌鳞癌细胞 Tca8113的作用。
Experimental study on the effect of Sapylin on cell growth of Tca 8113 is reported on as following.~3H-TdR incorporation test and colony forming test are applied to this study.The results show when concentration of Sapylin is 0.015 KE/ml to 0.000375 KE/ml,theinhibition rate of Tca8113 DNA synthesis is 53.8% to 61.3%;or when concentration is1.0 KE/ml,the colony forming rate is 0,8 days after incubation.It suggests thatone of the mechanisms of cell growth inhibition by Sapylin may probably be due toinhibition of DNA synthesis.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
1992年第4期247-248,288,共3页
West China Journal of Stomatology