维那利酮对犬实验性心力衰竭的影响

Effect of Chinese--made Vesnarinone on Experimental Heart Failure of Dog

用戊巴比妥钠诱发犬急性心力衰竭,经股静脉注射本院研制的维那利酮3mg,继之静脉滴注每分钟0.1mg/kg,共30分钟,研究其血流动力学。结果,给药后,心衰竭犬的心输出量与左室内压最大变化速率均显著增加,并呈剂量依赖性。停药后30分钟,二者仍有明显变化。实验中,未发现血压、心率的变化,表明维那利酮正性肌力作用较强,且具有相对选择性。

Intravenous drip of sodiumpentobarbital 6 mg/kg per min inducedobvious heart failure of anesthetic dogs(n=11) followed by an infusion of 0.25mg/kgper min to maintain the heart failure state.The Chinese-made vesnarinone 3 mg/kgwas injected, followed by an infusion of0.1mg/kg per min, or the solvent in thesame volume, for 30 min. Vesnarinone in-creased significantly and instantly the car-diac output and left ventricular maximum+dp/dt, which almost recovered to normalat the end of the infusion and also signifi-cantly increased 30 min after administra-tion. The positive inotropic effect of vesna-rinone was not accompanied by an increasein the heart rate and the blood pressure.The results of our experiment reveal thatthe Chinese-made vesnarinone has a po-tent and relatively selective positive actionon heart failure of dogs.