肝硬化患者的肺功能损害

Pulmonary Function Disturbances in Patients with Hepatic Cirrhosis

将52例失代偿期肝硬化患者的5项肺功能测定值与健康配对组比较,肝硬化患者的VC、TLC、D_LCO降低,RV/TLC增加(P<0.05～0.001);按可能的致病因素进行分类比较,以腹水对肺功的影响最明显,除上述4项指标的改变外,FRC也降低(P<0.01),血清白蛋白降低的患者(≤30g/L)与血清白蛋白未降低患者相比,显示VC_LTLC和D_LCO降低;排除腹水的影响,发现食道静脉重度曲张与RV/TLC升高和D_LCO下降也相关。文内还对上述改变的可能机制进行了讨论.

The results of five pulmo-nary function tests on 52 patients withuncompensated hepatic cirrhosis were pre-sented. Compared with matched healthyadults, the patients had decreased valuesof VC, TLC and D_LCO, and their RV/TLCincreased (P<0.05-0. 001). Possible patho-genic factors were investigated. The asci-tes showed evident influences on pulmon-ary function. In addition to the disordersdetected by the above 4 tests, FRC dere--ased in the patients with ascites. A com-parison between the patients with album-in below 30g/L and the patients with albu-min above 30g/L revealed that reducedplasma albumin also played role in decreas-ing VC,TLC and D_LCO. Besides the effectsof ascites, severe varices of esophagusshould have relation to the increase ofRV/TLC and the decrease of D_LCO.