急性心肌梗死溶栓疗效与血清CK-MB的关系

CORRELATION BETWEEN CK-MB WITH EFFECTS OF THROMBOLYTIC THERAPY FOR ACUTE MYOCARDIAL INFARCTION

目的 探讨急性心肌梗死 (AMI)患者溶栓治疗后肌酸激酶同工酶 -MB(CK -MB)变量曲线与患者转归的关系。方法 对 1 66例AMI患者施行溶栓治疗 ,同时在发病 90min及 5～ 7d内行心导管术的患者 ,分别测定其CK -MB的起始浓度及溶栓治疗 90min、3 ,6 ,1 2 ,2 4h的浓度变化。对所采集的资料进行统计分析 ,确定CK -MB的峰值及曲线范围。结果 CK -MB峰值与梗死部位相关 (P<0 .0 5) ,也与治疗时间相关 (P <0 .0 1 )。CK -MB峰值在溶栓治疗后 90min及 5～ 7d与梗死区的功能相关 (P <0 .0 5) ,而曲线范围则只在 90min与梗死区功能相关 (P <0 .0 5)。结论 CK -MB峰值与AMI患者梗死区功能、左室功能及溶栓治疗后的转归相关。

Objective Study on relationship between MBisoenzyme of creatine kinase(CK-MB)variables curve and outcomes after thrombolytic therapy for acute myocardial infarction(AMI). Methods We measured CK-MB initially and 90 minutes(min),and at 3、6、12、24hours(h) after thrombolysis in 166 patients with AMI also undergoing cardiac catheterication at 90 min and a t 5-7 days.Data were analyzed by SAS software,and CK-MBmaximums and curve areas were determined. Results CK-MB maximums related to infarct location(P<0.05) and time to therapy(P<0.01),.CK-MB maximums related to infarct zone function at 90 min(P<0.05) and at 5-7 days(P<0.05),curve area related only at 90 min(P<0.05). Conclusion CK-MB maximums related to infarct zone function,left ventricular function,and outcomes after thrombolysis for AMI.