摘要
辛伐他汀是洛伐他汀经半合成而得到的降胆固醇药。它是一种非活性的内酯化前体药物 ,通过肝脏水解成活性代谢产物或其衍生物而起作用 ,用于治疗高胆固醇血症。大量临床试验结果表明 ,辛伐他汀能够显著降低冠心病的发病率、死亡率 ,具有有效的调脂作用 ,副作用少 ,长期应用耐受性好 ,是最有效的降低LDL C药物之一。
Simvastatin is a cholesterol lowering agent that is partially synthesized from lovastatin. Simvastatin is an inactive lactonization precursor parmaceutical, it operate by active metabolites or its derivatives via liver hydrolyzation. Simvastatin can be used in curing hypeholesterol. Lots of clinical tests show that simvastatin can remarkably decrease incidence and death rate of coronary heart disease, which is characterized by effective adjusting blood lipid levels, few side effects and good endurance of long-term use. Simvastatin is one of the most effective LDL-C lowering drugs. Sichuan Industrial Institute of Antibiotics developed a technology of producing simvastatin which reached international advanced level.
出处
《精细与专用化学品》
CAS
2003年第10期16-18,共3页
Fine and Specialty Chemicals
