苯妥英局部应用治疗痛风并发难治性溃疡3例

The Effect of Phenytoin on Refractory Ulcers in Gout

本文报道局部应用苯妥英(PHT)治疗痛风并发顽固性溃疡3例,获得满意疗效。临床观察结果显示,PHT局部应用具有通畅引流,减轻溃疡创面炎症,促使创面细菌转阴,促进溃疡创面愈合等作用。局部使用PHT疗效确实、安全,值得推广应用。

Excellent results were obtaizied by using topical phenycion (FHT) in 3 gout patients with refractory ulcers. The gouty ulcers lasted for more than 1, 2 and 9 years respectively and were not healed by routine dressing change. The number of the ulcers was 4, 6 and 48 and the surface area of the ulcers varied from 0.5×0.5～4.5×6.5cm^2. Two cases had multiple deep fistulas or sinuses. The depth of the fistulsa varied from 6cm to 16cm. There was lots of chalky suppurative exudate on the ulcer surface or in the sinus. The bacterial cultures were positive in 2 cases, one was Pseudomonas aeruginosa, the other was staphylococci aureus. After topical application of PHT, the exudate began to diminished in the 5 th day, and even disappared In the 10th day. Fresh granulation grew in the 7th to 15th day. Bacterial cultures became negative in the 18th to 24th day. The time for coniplete healing was from 20 days to 80 days. 2 cases healed and one improved markedly. No adverse reaction was observed. The results suggested that PHT was effective and useful in the treatment of gouty ulcers. The topical use of PHT is safe and reliabe. It can be recommended as an ideal medicine for the therapy of refractory ulcers with gout. Further stucy on the broad range of clinical use of PHT is necessary.