高血压病患者血清肝细胞生长因子与低密度脂蛋白及左室重塑的关系

RELATIONSHIP BETWEEN LEVELS OF SERUM HEPATOCYTE GROWTH FACTOR AND LOW-DENSITY LIPOPROTEINS, LEFT VENTRICULAR REMODELING IN PATIENTS WITH ESSENTIAL HYPERTENSION

目的 :探讨高血压病患者血清肝细胞生长因子 (HGF)水平与低密度脂蛋白 (LDL)及左室重塑的关系。方法 :将 6 5例 2级原发性高血压 (EH)患者分成单纯高血压组、高低密度脂蛋白 (LDL)组和左室重塑组。用酶联免疫吸附法 (ELISA)测定血清HGF水平。结果 :血清HGF浓度与舒张压无显著相关 (r =0 .0 39,P >0 .0 5 ) ;而与收缩压及LDL浓度呈正相关 (分别r=0 .4 6 ,r =0 .6 7,均P <0 .0 5 ) ,且高LDL组和左室重塑组血清HGF均较单纯高血压组显著升高 (均P <0 .0 1) ,单纯高血压组较正常对照组明显升高 (P <0 .0 1)。结论 :血清HGF水平与左室重塑、LDL及高血压本身有关 ,HGF可作为判断高血压病严重程度的指标之一。

Objective:To investigate the relationship between serum HGF levels and LDL, left ventricular remodeling in patients with essential hypertension(EH).Methods: The serum HGF concentrations of 65 patients with EH were measured by ELISA.Results: There was no significant correlation between HGF level and diastolic blood pressure, and a significant positive correlation between HGF and systolic blood pressure, LDL was found.Furthermore, the serum HGF levels in patients with EH were higher than those in control( P <0.01). The serum HGF levels of EH patients with high LDL or left ventricular remodeling were significantly higher than those of EH patients without complication( P <0.01).Conclusion: The changes of .HGF level were correlated with high LDL, left ventricular remodeling and hypertension itself in patients with essential hypertension.HGF may be considered as one of indexes for the severity of EH.