摘要
采用胍与β-二羰基化合物缩合和嘧啶环上的亲核取代反应,合成了(a)～(p)共16个目标化合物,其中4个是新化合物,经改进合成方法和反应条件,使步骤简化或收率提高。产物结构经~1H NMR,IR和元素分析测试而确证。
Sixteen compounds of 2-Amino-4, 6-disubstituted pyrimidines are sgnthesized by Condensation of guanidine with β-dicarbonyl Compounds and nuclephilicsubstitution of Pyrimidines. Among them 4 are new Compounds. The Structures of tanget molecules have beem Confirmed by ~1H NMR, IR and elemental analysis. For the reaction's condidtions and methods were discussed.
出处
《华中师范大学学报（自然科学版）》
CAS
CSCD
1992年第4期465-470,共6页
Journal of Central China Normal University：Natural Sciences
基金
湖北省自然科学基金
关键词
取代嘧啶
合成
亲核取代反应
Substitutedpyrimidine
Sgnthesis Guanidine
Condensation
nuclephilic substitution
