敌敌畏诱发小鼠外周血中性粒细胞核突与微核的观察

OBSERVATIONS OF DDVP TO INDUCE THE OCCURRENCE OF IN PERIPHERAL BLOOD NEUTROPHIL NUCLEAR EXCRESCENCE AND MICRONUCLEI OF MICE

模拟敌敌畏的空气污染对小鼠进行处理,观察到随着敌敌畏投药处理的时间越长,小鼠外周血中性粒细胞核突和微核均值就越高,而又随停止投药处理后可恢复到处理前的水平。表明空气中的敌敌畏可诱发小鼠外周血中性粒细胞和微核,证明了可利用外周血中性粒细胞核突率和微核率作为新的生物学指标,来检测机体对药物,食品中毒以及环境污染等的反应。

The paper reports that when mice were treated in simulated air DDVPpollution, We observed the longer the time of treatment the higher the mice peripheral blood meutro-phil nuclear excrescence and micronuclei averages. And after DDVP treatment stoped, the averages returned to the level before treatmant. It shows that DDVP in air can induce peripheral blood neutrophil nuclear excrescence and micronuclei of mice. The result verifies that we might use this neutrophil nuclear excrescence and micronuclei incidence as a new biological index to detect the response of organism to toxic drugs and foodstuffs polluted environment etc.