青年乳腺癌微血管密度与其侵袭性关系

Correlation of microvessel density and the aggressiveness of breast cancer in young women

目的 探讨青年乳腺癌微血管密度与其侵袭性关系。方法 SABC免疫组化法检测 40例青年乳腺癌 (年龄≤ 3 5岁 )和 3 0例绝经期乳腺癌组织中微血管密度 (MVD )值 ,探讨其与腋窝淋巴结转移、临床病理特征之间的相互关系 ,比较两组之间的差异。结果 青年组腋窝淋巴结阳性率和MVD值 ( 70 %和 65 .2 8± 15 .0 6)均明显高于绝经组 ( 4 0 %和 5 1.91± 15 .0 6) ( P <0 .0 5和 P <0 .0 1)。MVD值与腋窝淋巴结转移和TNM临床分期有关 (P <0 .0 5和P <0 .0 1)。结论 青年乳腺癌侵袭性强与肿瘤血管生成有关。

Objective To determine the relationship between the microvessel density and the aggressiveness in breast cancer(BC) in young women (≤35years).Methods Immunohistochemical method (SABC) was used to study the expression of MVD on paraffin embedded sections in 40 young women BC patients(age≤35years) and 30 past menstrual BC patients.The relation between axillary lymph node metastasis and the clinicopathological parameters was analyzed and compared.Results The mean value of MVD and the positive rate of axillary lymph node in the young women group(65.28±15.06,70%)were higher than that in the past menstrual group(51.91±15.06,40%)(P<0.01or P<0.05 ).The mean value of MVD was related to the rate of axillary lymph node metastasis and the clinical stage of TNM of BC(P<0.05 or P<0.01).Conclusions Angiogenesis is directly related to the high aggressiveness in breast cancer in young women.