摘要
Proteins therapy is of great importance in the treatment of protein deficiency disease. Most human diseases are related to the malfunctioning of one or more proteins. The most effective and direct approach is protein therapy, which delivers the proteins into the target cell to replace the dysfunction protein and maintain the balance of organism. However, clinical application is frequently hampered by various biological barriers to their successful delivery. This review aims to discuss the recent advances about microparticles and nanoparticles fabricated using micro and nanotechnology for intracellular delivery therapy protein and give some suggestions about the promising delivery system.
Proteins therapy is of great importance in the treatment of protein deficiency disease. Most human diseases are related to the malfunctioning of one or more proteins. The most effective and direct approach is protein therapy, which delivers the proteins into the target cell to replace the dysfunction protein and maintain the balance of organism. However, clinical application is frequently hampered by various biological harriers to their successful delivery. This review aims to discuss the recent advances about microparticles and nanoparticles fabricated using micro and nanotechnology for intracellular delivery therapy protein and give some suggestions about the promising delivery system.
基金
supported by the program of Ma jor scientific and technological specialized project for "significant new formulation of new drugs" (No. 2009ZX09310-007 and No. 2009ZX09301007)
National Science Foundation of China Committee (No. 30873180)
Foundation of Ministry of Education of China (No. 20090073120085)
the Shanghai Science and Technology Committee (No. 0952nm03700 and No. 0952nm03700)
The authors thank the Analytical Center of Shanghai JiaoTong University for Technical Support
