摘要
亚急性硬化性全脑炎 (SSPE)是由缺陷型麻疹病毒引起的严重的中枢神经系统疾病。此病的特征是智力减退 ,节律性肌阵挛伴典型的脑电图改变 ,脑脊液IgG增多 ,血清和脑脊液中抗麻疹抗体水平升高。此病呈进行性发展 ,病人一般于发病后 1～ 3年死亡。虽然一些药物可缓解病情 ,但目前仍无特效治疗。麻疹疫苗接种可显著降低SSPE发病率。
Subacute sclerosing panencephalitis(SSPE)is a serious disorder of central nervous system caused by defective measles virus.It is characterized by a progressive loss of intellectual functioning,rhythmic myoclonic movements with a typical electroencephalogram pattern,elevated cerebral spinal fluid(CSF)IgG,and elevated serum and CSF anti-measles antibody titers.The disease has a gradual progressive course and most patients die 1 to 3 years after the onset.Though some drugs show effective to slow down the progression of the disease,yet no specific treatment has been discovered.Vaccination against measles is still the only effective mean for decreasing the incidence of SSPE.
出处
《中国计划免疫》
2003年第2期120-123,共4页
Chinese Journal of Vaccines and Immunization
关键词
亚急性
硬化性全脑炎
麻疹免疫
发病机理
诊断标准
治疗
Subacute sclerosing panencephalitis
Pathogenesis
Pathological changes
Clinical features
Diagnosis
Treatment
Measles immunization
