摘要
采用最大给药量法给小鼠灌胃薏苡仁油纳米微乳,剂量为9.0g·kg-1,以检测薏苡仁油微乳的生物安全性。结果表明:在连续观察14d期间试验组小鼠生长发育良好,小鼠体重、行为活动、食物利用率、分泌物和排泄物等各项指标均在正常范围内,与对照组相比无显著性差异(P>0.05)。薏苡仁油纳米微乳在常规剂量下是安全、可靠的。
The study aimed to evaluate the biologic safety of Coix Oil Micro-emulsion(COME)by using the intragastric administration to mice with single maximal 9.0g/kg doses.The results showed that the experimental groups were in good health state,with the behaviors,body weight,food intake rate,secretion and excrement in the normal range.There were no obvious difference between the experimental groups and the control(P>0.05).The results showed that COME dose is safe and reliable when taking under the conventional.
出处
《南昌大学学报（理科版）》
CAS
北大核心
2015年第1期91-95,共5页
Journal of Nanchang University(Natural Science)
基金
国家863计划项目(2008AA10Z332)
江西省教育厅项目(2013)
