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钠碘转运体转基因介导放射性碘治疗非甲状腺恶性肿瘤的研究进展 被引量：4

A targeted radioiodide theraty in non-thyroid malignant tumor following transfection of the sodium/iodide symporter gene
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摘要 钠碘转运体 (NIS)是一种能介导碘向细胞内转运的膜蛋白 ,可以配合放射性碘来治疗肿瘤。目前已经利用转基因技术使不表达或低表达NIS的非甲状腺恶性肿瘤细胞表达NIS蛋白。同时发现肿瘤细胞的低摄碘能力与NIS合成的量及NIS是否能正确锚着密切相关。当前努力的方向除促进NIS的表达和锚着 ,还要研究如何使肿瘤细胞摄入的碘能够在细胞内滞留足够长的时间以达到杀伤肿瘤的目的。目前已经在乳腺、前列腺、绒毛膜癌。
作者 贾悦 唐伟 刘超
机构地区 南京医科大学第一附属医院内分泌科
出处 《国外医学（肿瘤学分册）》 2003年第3期197-199,共3页 Foreign Medical Sciences (Cancer Section)
基金 国家自然科学基金资助项目 ( 3 9970 3 5 1)
关键词 非甲状腺恶性肿瘤 基因治疗 钠碘转运体 转基因技术 放射性碘 乳腺癌 前列腺癌 绒毛膜癌 肺癌
分类号 R730.5 [医药卫生—肿瘤]
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参考文献18

  • 1Dohan O, De la Vieja A, Carrasco N. Molecular study of the sodium-iodide symporter(NIS) : a new field in thyroidology[J ]. Trends Endocrinol Metab,2000, 11(3): 99-105.
  • 2Spitzweg C, Joba W, Eisenmenger W, et al. Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa [ J ]. J Clin Endocrinol Metab, 1998, 83(5) : 1746-1751.
  • 3Smit JW, Shroder van der Elst JP, Karperien M, et al. Reestablishment of in vitro and in vivo iodide uptake by transfection of the human sodium iodide symporter (hNIS) in a hNIS defective human thyroid carcinoma cell line[J]. Thyroid,2000, 10(11 ): 939-943.
  • 4Spitzweg C, Harrington KJ, Pinke LA, et al. The sodium iodide symporter and its potential role in cancer therapy[J ]. J Clin Endocrinol Metab,2001, 86(7) :3327-3335.
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同被引文献38

  • 1贾悦,刘超,覃又文,刘翠萍,唐伟,袁庆欣,狄福松.维甲酸对乳腺癌细胞MDA-MB453钠碘转运体调控(英文)[J].中国现代医学杂志,2004,14(21):11-14. 被引量：2
  • 2Levy O, Vieja A, Ginter CS, et al. N - linked glyeosylation of the thyroid Na^+/I^- symporter[J]. J Biol Chem, 1998, 273:22 657 - 22 663.
  • 3Varyre L, Sabourin JC, Caillo B, et al. hnmunohistochemical analysis of Na^+/I^- symporter distribution in human extra - thyroid tissues [ J ]. Eur J Endocrinol, 1999,49 : 517 - 523.
  • 4Ajjan RA, Kamaruddin NA, Crisp M, et al. Regulation and tissue distribution of the human sodium iodide symporter gene [ J ]. Clin Endocrinol Oxf, 1998,49:517 - 523.
  • 5Spitzweg C, Joba W, Eisenmenger W, et al. Anolysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acid from salivery gland, mammary gland, and gastric mucosa [ J ]. J Clin Endocrinol Metab, 1998,83 : 1 746 - 1 751.
  • 6Dai G, Levy O. Carrasco N. Cloning and eharateriztion of the thyroid iodide transporter[ J ]. Nature. 1996,379:458 - 460.
  • 7Smank PA, Liu Q, Furminger TL, et al. Cloning of the human sodium iodide symporter[ J ]. Biochem Biophys Res commun, 1996,226:339 - 345.
  • 8Manell RB, Mendlell IZ, link CJ. Radioisotope concentrator gene therapy using the sodium/iodide symporter gene [ J ]. Cancer Res, 1999,59:661 - 668.
  • 9Shimura H, Haraguehi K, Miyazaki A, et al. Iodide uptake and experimental ^131I therapy in transplanted undifterentiated thyroid cancer cells expressing the Na ^+/I^- symporter gene [J]. Endocrinology, 1997,138 ( 10 ) :4 493 - 4 496.
  • 10Cho JY, Xing S, Liu X,et al. Expression and activity of human Na ^+/I^- symporter in human glioma cells by adenovirus mediated gene delivery [ J ]. Gene Ther,2000,7 (9) :740 - 749.

引证文献4

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国外医学（肿瘤学分册）
2003年 第3期

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