愈肝片对实验性大鼠急慢性肝损伤的保护作用

Protective Effectes of Yugan Table on Acute and Chronic Hepatic Injury in Rats

目的 :探讨愈肝片对大鼠D 氨基半乳糖急性肝损伤和四氯化碳慢性肝损伤的保护作用。方法 :分组造模给药后测定大鼠血清中AST、ALT、TP、ALB和出凝血时间的变化 ,取肝组织做病理学检测。结果 :愈肝片能降低D 氨基半乳糖急性肝损伤大鼠血清AST、升高白蛋白ALB ,改善出凝血时间 ,可明显减轻肝组织变性、坏死程度 ;并能降低四氯化碳慢性肝损伤大鼠血清AST、ALT ,升高ALB、TP。结论 :愈肝片对D氨基半乳糖和四氯化碳所致的急慢性肝损伤有保护作用。

Objective:To explore the protective effects of Yugan Yabs on D GlaN induced acute hapar injury and CCl 4 induced chronic hapar injury of mice.Methods:The mice were randomly devided into six groups,We detected the serum AST、ALT、TP、ALB、clotting time and liver tissues of hapar injury mice model after be given Yugan Yabs.Results:In D GlaN induced mice acute hapar injury experiment,Yugan Yabs can lower serum AST、elevate serum ALB、shorten clotting time、abate destructure and necrosis of liver tissues.In CCl 4 induced mice chronic hapar injury experiment,Yugan Yabs can lower serum AST and ALT,elevate serum ALB and TP.Conclusions:Yugan Yabs have protective effectes both on D GlaN induced acute hapar injury and CCl 4 induced chronic hapar injury.