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干细胞在放射医学研究中的进展 被引量:1

The advancement of stem cells in radiation medicine
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摘要 电离辐射作用于机体后,可致机体发生急性放射病。辐射损伤的远后效应之一是白血病,含有干细胞的骨髓细胞移植是目前挽救急性放射病病人生命的惟一有效的治疗方法。近年来随着干细胞研究的突破性进展,其多向分化潜能及干细胞相互转化可能为辐射损伤病人提供新的干细胞来源;同时随着辐射防护剂研究的深入,促进了损伤后干细胞的恢复。 It may result in acute radiation syndrome after body is exposed to ionizing radiation.The one of long-term ef-fects of irradiation injury is leukemia.The bone marrow cells(BMC)transplantation including stem cells is the only effec-tive therapy for acute radiation syndrome patients.Recently,with the advancement of stem cell research that the stem cells have multipotential and can convert each other,it may supply the new stem source for the irradiation injury patients.At the same time with the further research of radioprotective reagents,the hematopoietic stem cells proliferation after irra-diation injury is promoted.
作者 郭丽 范洪学
机构地区 吉林大学
出处 《国外医学(放射医学核医学分册)》 2003年第2期80-83,共4页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
基金 吉林省卫生厅医学科研基金项目(200131)
关键词 干细胞 放射医学 研究进展 急性放射病 辐射损伤 stem cells radiation medicine hemopoietic stem cells
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参考文献15

  • 1Bjornson CR, Rietze RL, Reynolds BA, et al. Turning braininto blood: a hematopoietic fate adopted by adult neural stem cells in vivo[J]. Science, 1999, 283(5401 ): 534-537.
  • 2Woodbury D, Schwarz EJ, Prockop DJ, et al. Adult rat and human bone marrow stromal cells differentiate into neurons[J]. J Neurosci Res, 2000, 61(4): 364-370.
  • 3Wang JS, Shum-Tim D, Galipeau J, et al. Marrow stromal cells for cellular cardiomyoplasty: feasibility and potential clinical advantages[J]. J Thorac Cardiovasc Surg, 2000,120(5): 999-1005.
  • 4Akerud P, Canals JM, Snyder EY, et al. Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease[J]. J Neurosci, 2001, 21(20): 8108-8118.
  • 5Thomas ED. Landmarks in the development of hematopoietic cell transplantation[J]. World J Surg, 2000, 24(7): 815-818.
  • 6Chute JP, Clark W, Saini A, et al. Rescue of hematopoietic stem cells following high-dose radiation injury using ex vivo culture on endothelial monolayers[J]. Mil Med, 2002, 167(2Suppl): 74-77.
  • 7Perkins AC. Enrichment of blood from embryonic stem cells in vitro[J]. Reprod Fertil Dev, 1998, 10(7-8): 563-572.
  • 8Jackson KA, Mi T, Goodell MA. Hematopoietic potential of stem cells isolated from murine skeletal muscle[J]. Proc Nail Acad Sci USA, 1999, 96(25): 14482-14486.
  • 9Na Nakom T, Traver D, Weissman IL, et al. Myeloerythroidrestricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S [J]. J Clin Invest,2002, 109(12): 1579-1585.
  • 10Hudak S, Leach MW, Xu Y, et al. Radioprotective effects of flk2/flt3 ligand[J]. Exp Hematol, 1998, 26(6): 515-522.

同被引文献16

  • 1滕莉,王凤山,刘爱华.抗氧化剂在辐射防护中应用的研究进展[J].中国药学杂志,2005,40(19):1444-1448. 被引量:3
  • 2郑辉,赵乃坤,刘秀敏,甄荣,陈惠芳.小鼠电离辐射损伤后血液和肝细胞浆抗氧化酶活力变化的特点[J].中国辐射卫生,1996,5(4):233-235. 被引量:2
  • 3Spradling A, Drummond-Barbosa D, Kai T. Stem CellsFind their Niche[j]. Nature, 2001,414:98.
  • 4Zuk P A, Zhu M, Ashijian P, et al Human Adipose Tis-sue is a Source of Multipotent Stem Cells [ J]. MolecularBiology of the Cell, 2002,13:4279.
  • 5Kem S, Eiehler H, Stoeve J, et al Comparative Analysisof Mesenchymal Stem Cells from Bone Marrow, UmbilicalCord Blood or Adipose Tissue[ J] . Stem Cells, 2006,24:1294.
  • 6Gutteride J M, Halliwell B. Comments on Review of FreeRadicals in Biology and Medicine[ J]. Free Radical Biolo-gy and Medicine, 1992:12( 1) : 93.
  • 7Cetin T,Arpaci M, Yilmaz I,et al Oxidative Stress inPatients Undergoing High-Dose Chemotherapy Plus Periph-eral Blood Stem Cell Transplantation [ J] . Biological TraceElement Research,2004,97 : 237.
  • 8Peterson K M, Aly A, Leiman A, et al Improved Survivalof Mesenchymal Stromal Cell after Hypoxia PreconditioningRole of Oxidative Stress [ J]. Life Sciences, 2011, 88( 1-2):65.
  • 9Haton C, Vandamme M, Wysocki J, et al Imbalance ofthe Antioxidant Network of Mouse Small Intestinal Mucosaafter Radiation Exposure [J]. Radiation Research, 2007,167:445.
  • 10涂序珉,郑辉,甄荣,廖京辉,张志兴.辐射损伤后不同阶段细胞内外抗氧化酶活性和丙二醛含量变化的研究[J].中华放射医学与防护杂志,2008,28(1):49-52. 被引量:7

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