^(131)I对甲状腺细胞凋亡的影响

The role of ^(131)I on apoptosis of thyrocytes in vitro

由于每个患者特异性基因决定的个体辐射敏感性不同,使得每个接受131I治疗的患者对治疗的反应不一,因而疗效差异较大。针对不同的个体,采用不同的剂量治疗才可以提高131I治疗的效率,降低甲状腺功能减退症的发病率。通过目前的分子生物学技术,我们已经了解到一些基因的蛋白表达产物(Fas/FasL、Bcl-2等)与细胞凋亡和射线诱导凋亡的联系,使对凋亡基因表达产物的体外监测成为可能。也许通过对这些指标的监测,可以使我们在131I治疗过程中实现对不同的个体给予恰当的个体剂量。

The individual sensitivity of radiation is determined by specialized gene of people,so the patient with differ-ent radiotherapy dose has different results.Coinciding every patient with individual dose can improve the effect of radio-therapy,lower the incidence of hypothyroidism.Using modern molecular biology techniques,we have understood the re-lationships between several genes' products(Fas /FasL and Bcl-2et al.)and apoptosis(or rays induced apoptosis),and all these methods and techniques make it possible for us to measure the products in vitro.Maybe in the future we can mea-sure the index during the period of radiotherapy and use the suitable dose.