西咪替丁对尖锐湿疣术后复发的预防作用

Clinical Observation and Immune Control Action of Cimetidine for Treating Condyloma Acuminatum

目的 探讨西咪替丁对尖锐湿疣 (CA)术后复发的预防作用。方法 治疗组 19例 ,采用手术联合西咪替丁 ( 2 0 0mg ,3次 /d ,连用 2个月 )治疗 ;对照组 17例 ,单纯手术治疗。同时采用双抗体夹心ELISA技术 ,检测CA患者治疗前后血清IL 2水平。术后 3个月评定疗效。结果 两组患者IL 2水平均低于正常组。治疗组用药后血清IL 2水平明显升高 (P <0 .0 5 ) ,其治愈率和复发率分别为 89.47%和 10 .5 3 % ;对照组为 5 2 .94%和 47.0 6 %。两组治疗后的复发率比较有显著性差异 ( χ2 =4.2 9,P <0 .0 5 )。结论 手术联合西咪替丁治疗尖锐湿疣可增加其治愈率 ,减少复发率。西咪替丁对尖锐湿疣术后的复发有预防作用。

Objective To study the preventive role of cimetidine in condyloma acuminatum (CA) relapse after operation.Methods 19 cases of CA were treated with the operation and cimetidine(200 mg,tid,2 mo),and compared with 17 patients only with operation,in the same time,IL-2 in serum was tested with ELISA before and after treatment.The therapeutic response were evaluated after 3 monthes.Results The level of IL-2 in CA patients was lower than that of normal.It increased after treatment in both of two groups,it was significantly higher in therapeutic group than that control group(P<0.05).The cure and relapse rate of the therapeutic group were 89.47% and 10.53% respectively,and that of the control group were 52.94% and 47.06%.Compared two groups,there was significant difference (χ 2=4.29,P<0.05).Conclusion Combined operation with cimetidine for CA may increase cure rate and reduce relapse rate.Cimetidine plays the preventive role in CA relapse after operation.