智力竞技型休闲活动对阿尔茨海默病的影响

Effect of recreational activities of intelligence tournament on Alzheimer's disease

目的 探讨智力竞技型休闲活动 (以下简称智力活动 )对阿尔茨海默病 (AD)的影响。方法 采用分层随机整群抽样方法 ,以淄博市各层人口所占总人口比例确定各层应查≥ 5 5岁人群 ,共 6 5 6 0人 ,实查 6 348人。调查采用筛查和确诊两阶段法 ,按美国精神障碍诊断与统计手册第 4版的标准诊断痴呆 ,同时进行自编智力活动问卷调查 ,并进行流行病学及卫生统计学分析。结果 (1)查出痴呆患者共 138例 ,患病率为 2 17%。其中AD为 1 6 1% ,血管性痴呆 (VD)为 0 4 1% ,其他痴呆为0 16 %。 (2 )有智力活动组的AD患病率 (0 6 7% ,11例 )低于无智力活动组 (1 94 % ,91例 ;P <0 0 1)。(3)分层分析结果显示 ,同一层中有智力活动组的AD患病率均低于无智力活动组 (P <0 0 5和P <0 0 1)。 (4)有智力活动组的AD患病年龄 [(84± 7)岁 ]较无智力活动组 [(71± 8)岁 ]晚 (P <0 0 1) ;且痴呆的程度 (中、重度为 0 2 4 % )较无智力活动组 (1 70 % )轻 (P <0 0 1)。结论 智力活动有助于降低罹患AD的风险 ,对AD可能有保护作用。

ObjectiveTo study the effect of recreational activities of intelligence tournament (simply called intelligence activities) on Alzheimer′s disease (AD). MethodsThe residents aged 55 years or over in the urban and rural areas in Zibo were studied by stratified random cluster sampling. The number of the elderly from each level was determined according to the basic proportion of the relevant level in the population of Zibo. Each elderly was interviewed face to face with the Mini-Mental State Examination (MMSE) and self-compiled questionnaire for assessing the intelligence activities. The subjects with cognitive impairment according to the MMSE score were screened out and assessed with a battery of neuropsychological examination and Pfeiffer functional scale. The clinical diagnosis of dementia was made according to the 4th Edition of Diagnosis and Statistical Manual of Mental Disorder criteria. The data were done with epidemiological and hygienic statistics analysis. ResultsAmong the total of 6 560 elderly sampled, 6 348 subjects were interviewed. The prevalence rate of dementia was 2.17%, in which AD was 1.61%, vascular dementia (VD) 0.41%, and other dementia 0.16%. The prevalence of AD in the elderly with intelligence activities was lower than that in those with non-intelligence activities (0.67% vs. 1.94%;P <0.01). And the similar findings were in each stratified level ( P <0.05- P <0.01). The onset age of the AD patients with intelligence activities was older ( P <0.01) and the AD severity was milder ( P <0.01) than those without. ConclusionThe intelligent activities may lower the risk of AD and be a protective factor for AD.