强迫症、抑郁症及焦虑症患者事件相关电位的比较研究

A comparative study of event-related potentials in patients with obsessive compulsive disorder,depression or anxiety

目的 探讨强迫症 (OCD)、抑郁症 (CD)及焦虑症 (CA)患者三种事件相关电位 (ERP)的变异。方法 应用美国NicoletSpirit脑诱发电位仪 ,采用光和声成对刺激、反应时间以及听觉靶 非靶刺激序列技术 ,检测 31例OCD、2 0例CD和 17例CA及 2 8名正常人 (NC)的关联性负变 (CNV)、P3 0 0 及失匹性负波 (MMN)。结果 (1)CNV :M1波幅CD组 [(5± 4 ) μV]和CA组 [(7± 4 ) μV]低于NC组 [(14±6 ) μV]和OCD组 [(16± 6 ) μV ;P <0 0 5和P <0 0 1]。指令信号后负变化的出现率CD组 (6 0 % )、OCD组 (45 % )和CA组 (35 % )均高于NC组 (4% ;P <0 0 1)。 (2 )P3 0 0 :在靶刺激中 ,N2 潜伏期在四组间的差异有非常显著性 (P <0 0 1) ,其中OCD组 [(2 78 9± 2 2 7)ms]和CD组 [(2 77 3± 2 1 8)ms]的潜伏期均长于NC组 [(2 5 9 0± 14 0 )ms],CA组短于CD组和OCD组 (P <0 0 1) ;P3 波幅在四组间的差异亦有非常显著性 (P <0 0 1) ,其中OCD组 [(3 4± 1 5 ) μV]、CD组 [(2 9± 1 3) μV]和CA组 [(3 3± 1 3) μV]均低于NC组 [(5 9± 2 1) μV]。在非靶刺激中 ,CA组P2 波幅低于OCD组和NC组 (P <0 0 5 )。 (3)MMN :OCD组、CD组及NC组之间潜伏期和波幅的差异有显著性和非常显著性 (P <0 0 5和P <0 0 1)。其中OCD?

ObjectiveThe present study was to investigate the variations of contingent negative variations (CNV), P_ 300 , and mismatch negative (MMN) in patients with obsessive compulsive disorder (OCD), depression, or anxiety. MethodsThirty-one patients with OCD, 20 with depression (CD), 17 with anxiety (CA) and 28 normal controls (NC) were involved. The event-related potentials (ERP) CNV, P_ 300 , and MMN were recorded with Nicolet Spirit Instrument. ResultsThe PINV emergence rate and amplitude (M_1) of CNV in the patient groups were significant different from NC ( P <0.01). Compared with NC group, CD and CA, but not OCD patients had decreased M_1 amplitude ( P <0.01). And a significant difference of P_ 300 among 4 subject groups was found in latencies (Cz/N_2),P_3 and nontarget-P_2 amplitudes ( P <0.05-0.01). The MMN presentation in patients with OCD, and CD was similar to that of P_ 300 changes. ConclusionCNV, P_ 300 and MMN are useful indexes for assessing the brain malfunction in CD,OCD and CA patients. The characteristics of ERP might be useful indexes in distinguishing OCD patients from CD ones.