非妊娠性绒毛膜癌17例临床分析

Clinical analysis of 17 cases of nongestational choriocarcinoma

目的 探讨非妊娠性绒毛膜癌 (绒癌 )的诊断、治疗及其与预后的关系。方法 对北京协和医院 1 985～ 2 0 0 1年间 ,收治的非妊娠性绒癌 1 7例 (女性 1 1例 ,男性 6例 )的临床资料进行回顾性分析。结果 初诊明确诊断者 3例 ;所有患者均接受了包括化学药物治疗 (化疗 )和手术的综合治疗。平均化疗疗程数 8.6个 ;9例女性和 2例男性患者 ,治疗后病情获完全缓解。随诊 8～ 1 1 8个月无复发。结论 非妊娠性绒癌的诊断率有待提高。多药联合化疗结合手术治疗女性非妊娠性绒癌 ,可获满意效果。

Objective To evaluate the diagnosis, treatment and prognosis of nongestational choriocarcinoma Methods Retrospective analysis was done on 17 cases (11 female patients and 6 male patients) of nongestational choriocarcinoma treated in Peking Union Medical College Hospital from 1985 to 2001 Results All cases received operation as well as chemotherapy The mean courses of chemotherapy for each patient is 8.6 Correct diagnosis at the first administration was seen in only 3 cases Nine female and 2 male patients obtained complete remission after the treatment and no recurrence was seen during the 8 to 118 months of follow up Conclusions The diagnosis of nongestational choriocarcinoma is expectecd to be promoted Optimal prognosis can be gained for the female patients after treatment by operation as well as chemotherapy, but the prognosis for the male patients is poor