肝细胞靶向甘草次酸表面修饰脂质体的制备

Preparation of Liposomes Surface-modified with Glycyrrhetinic Acid Targeting to Hepatocytes

目的 :研制靶向于肝细胞的甘草次酸表面修饰脂质体。方法 :化学合成 3 琥珀酸 30 硬脂醇甘草次酸酯 (Suc GAOSt)作为导向分子 ,采用乙醇注入法制备甘草次酸表面修饰脂质体 (LP SM GA)。结果 :Suc GAOSt确能掺入脂质膜中 ,掺入比例最高可达总脂质的 9%。结论 :LP SM GA制备成功 ,可作为肝细胞主动靶向给药的潜在途径。

Objective: To study the preparation of liposomes surface modified with glycyrrhetinic acid targeting to hepatocytes. Method: 3 succinic 30 stearyl glycyrrhetinic acid(Suc GAOSt), one of the amphiphilic glycyrrhetinic acid derivatives, was synthesized as targeting molecules, liposomes surface modified with glycyrrhetinic acid has been produced with ethanol injection method. Result: Targeting molecules can be mixed into the liposomal membrane. It was confirmed that the targeting molecules is 9% of the total lipids at the most in the liposomes. Conclusion: Liposomes surface modified with glycyrrhetinic acid was successfully prepared,which is considered to be a potential approach targeting to hepatocytes. [