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组蛋白乙酰化/去乙酰化及其在恶性血液病中的研究进展 被引量：2

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摘要 组蛋白乙酰化/去乙酰化是调控基因表达的重要方式之一.目前认为组蛋白乙酰化可促进基因表达,而组蛋白去乙酰化可抑制基因表达.组蛋白去乙酰化酶抑制剂通过竞争性抑制组蛋白去乙酰化酶,使组蛋白乙酰化过程增强。促进基因的表达.白血病中许多染色体易位均涉及组蛋白去乙酰化酶或因组蛋白去乙酰化酶的活性异常,引起抑癌基因表达抑制或癌基因激活和过度表达,导致白血病的发生.在淋巴瘤的发病中,许多类型的淋巴瘤有明确的基因突变,可以产生一些新的基因,如bcl-6基因,导致淋巴瘤的发生.组蛋白去乙酰化酶抑制荆(histone deacety-lase inhibitors,HDAIS)是一类抗恶性血液病的化疗新药.体内和体外实验均显示HDAIS可抑制白血病细胞、淋巴瘤细胞增殖,使细胞周期受阻,诱导肿瘤细胞的分化和/或凋亡.组蛋白去乙酰化酶抑制剂在抗恶性血液病中发挥重要的作用.
作者 刘红利 陈燕
机构地区 华中科技大学同济医学院附属协和医院血液学研究所武汉
出处 《现代临床医学生物工程学杂志》 2003年第2期146-148,共3页 Journal of Modern Clinical Medical Bioengineering
关键词 组蛋白乙酰化 去乙酰化 恶性血液病 研究进展 基因表达
分类号 R733 [医药卫生—肿瘤]
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参考文献13

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同被引文献15

  • 1陆莹,杨爽,马珊珊,李呼伦,于波.组蛋白脱乙酰基酶2在血管紧张素Ⅱ致心肌细胞肥大中的表达[J].中国地方病学杂志,2005,24(4):392-395. 被引量：1
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  • 7Lee TM, Lin MS, Chang NC, et al. Inhibition of histone deacetylase on ventricular remodeling in infarcted rats[J]. Am J Physiol Heart Circ Physiol, 2007, 293(2):H968-H977.
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  • 9Kee HJ,Sohn IS,Nam KI,et al.Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin Ⅱ infusion and aortic banding[J].Circulation,2006;113(1):51-9.
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现代临床医学生物工程学杂志
2003年 第2期

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