利多卡因对重型颅脑损伤患者血浆降钙素基因相关肽、钙调素及预后的影响

The Effect of Lidocaine on Plasma Calcitonin Gene Related Peptide , Calmodulin and prognosis in Severe Craniocerebral Injury Patients

目的 为观察利多卡因对重型颅脑损伤患者血浆降钙素基因相关肽、钙调素水平及其预后的影响。方法 将 6 4例重型颅脑损伤患者按随机原则分成利多卡因治疗组和常规治疗组 ,分别测定治疗前及治疗开始后第 2、4、7天血浆CGRP、CaM含量 ,伤后 6个月进行预后判断并进行比较分析。结果 重型颅脑损伤后患者血浆CGRP水平下降而CaM水平升高 ,利多卡因治疗后可使上述改变显著减轻并显著改善患者预后 (P<0 .0 5 )。结论 重型颅脑损伤后血浆CGRP水平下降而CaM水平升高 ,参与了继发性脑损伤的病理生理过程 ,早期应用利多可因治疗可通过对CGRP和CaM水平的影响 ,减轻继发性脑损伤 。

Objective To study the effect of lidocaine on plasma calcitonin gene related peptide(CGRP), and calmodulin(CaM) and prognosis in severe craniocerebral injury (SCI) patients. Methods 64 cases SCI patients were divided into lidocaine therapy group and routine therapy group randomly, then examine the level of CGRP and CaM at beginning and the 2,4,7day after the begin of therapy seperatively, and evaluated the prognosis, the data were tested with χ 2 or t test. Results The level of CGRP fall but raise in CaM after SCI. Lidocaine therapy not only belittle the change but also improve the patients', prognosis significantly (P<0.05) . Conclusion The level were fallen of CGRP but rised in CaM after SCI, and were related with secondary injury of the brain, so earlier lidocaine therapy can protect brain from secondary injury through affect the level of CGRP and CaM.