卡维地洛治疗充血性心力衰竭的临床疗效评价

Clinical Effects of Carvedilol in Patients with Congestive Heart Failure

目的 :评价卡维地洛 (carvedilol)治疗充血性心力衰竭的临床疗效及机理。方法 :5 6例CHF患者随机分为两组 :常规治疗组 2 6例应用洋地黄、利尿剂及转换酶抑制剂等药物治疗 ;卡维地洛组 3 0例在常规治疗基础上加用卡维地洛。治疗前后分别行超声心动图、血常规及血生化检查。结果 :治疗 3个月后两组心功能均有显著改善 ,但卡维地洛组的改善比常规组更明显。结论 :卡维地洛可改善心功能 ,延缓心室重构 。

Objective: To evaluate the clinical effects and the mechanisms of carvedilol in patients with congestive heart failure (CHF, New York Heart Association functional class Ⅲ-Ⅳ ). Methods: Fifty-five CHF patients were randomly divided into two groups. One is conventional treatment group (n=26) treated with digitalis, diuretics, and vasodilatation including ACEI; and another is carvedilol treatment group (n=30) treated with carvedilol and conventional therapy. Echocardiogram, blood routine examination and blood biochemical examination were done bofore and after treatment. Result: After treated for three months, the cardiac function improved markedly in both groups, but that in carvedilol treatment group improved more significantly than that in conventional treatment group. Conclusion: Carvedilol has a cardiac protective effect in patients with congestive heart failure, in improving cardiac function and decreasing ventricular remodeling progress.