DDP和沙培林胸腔用药联合NP方案对肺癌合并恶性胸腔积液近远期疗效的观察

Clinical observation of combination chemotherapy and intrapleural injection of Sapylin and Cisplatin on malignant pleural effusions

目的 观察DDP和沙培林胸腔用药联合NP方案全身化疗治疗肺癌合并恶性胸腔积液的近远期疗效。方法 32例肺癌合并恶性胸腔积液患者随机分成两组 ,A组 :1 6例 ,胸膜腔内单用药组 ,使用DDP和沙培林 ,B组 :1 6例 ,胸膜腔内用药并联合使用NP(NVB +DDP)方案全身化疗。结果 ①A、B两组胸水控制短期有效率分别为 75 %和 87.5 % ,总有效率为 81 .3% ,两组比较无显著性差异 (P >0 .0 5 )。②A组1年、2年生存率分别为 4 3.75 %和 6 .2 5 % ,B组分别为 6 2 .5 %和 31 .2 5 % ,两组比较有显著性差异 (P <0 .0 5 )。结论 DDP和沙培林胸腔用药能有效控制胸水 ;

Objective To study the curative effect of intrapleural injection of Sapylin and Cisplatin in combination with NP regimen adjuvant chemotherapy. Methods 32 patients were divided into two Groups:16 patients were treated with intrapleural injection of Sapylin and Cisplatin(A gronp),16 patients were treated with intrapleural injection of the same drugs in combination with NP regimen adjuvant chemotherapy(NVB+DDP)(B group). Results ① The short term effective rates of A and B group were 75% and 87.5% respectively. The total effective rates was 81.3% , the difference was not significant( P > 0.05 ). ② The 1 year, 2 year survival rates of A group were 43.75% and 6.25% ,respectively,while the 1 year, 2 year survival rates of B group were 62.5% and 31.25% ,the difference was significant( P < 0.05 ). Conclusion The results showed that intrapleural injection of Sapylin and Cisplatin was effective in controlling malignant pleural effusions and that NP regimen adjuvant chemotherapy on the basis of intrapleural injection may help improving the survival rate.