1Liu Y, Snow BE, Honde MP, et al. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo[J].Carr Biol,2000,10(22):1459-1462.
2MuKai S, Kondo Y, Kaga S, et al. 2- 5A antisense telomerase RNA therapy for intracranial malignant gliomas[J]. Cancer Res,2000,60(16):4461-4467.
3Wen Zhong, Xiao Jianyan, Tian Yongquan, et al. Down-regulation of telomerase and hTR and apoptosis in the HNE1 cell lines of nasopharyngeal carcinoma induced by hTR anti-sense oligo-nucleotide[J].International J of Modern Cancer Therapy, 2000,3(1):77-81.
4NaKayama JI, Tahara H, Tahara E, et al. Telomerase activation by hTER in human normal fibroblasts and hepatocellular carcinomas[J].Nature Genetics, 1998,18:65-68.
5Zhang A, Zheng C, Lindvall C, et al. Frequent amplification of the telomerase reverse transcriptase gene in human tumors[J]. Cancer Res, 2000,60 (22):6230-6235.
6Yokoyama Y, Takahashi Y, Shinohara A, et al. The 5'-end of hTERT mRNA is a good target for hammerhead ribozyme to suppress telomerase activity[J]. Biochem Biophys Res Commun, 2000, 273(1):316-321.
7Xu D, Wang Q, Gruber A, et al. Down-regulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells[J]. Oncogene,2000,19(45):5123-5133.
8Tzukerman M, Shachaf C, Revel Y, et al. Identification of a novel transcription factor binding element involve in the regulation by differentiation of the human telomerase (hTERT) promoter[J]. Mol Biol cell, 2000,11(12) : 4381-4391.
9Gu J, Kagawa S, Takakura M, et al. Turnor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers[J]. Cancer Res, 2000,16(19):5359-5364.
10Mac SM, D'Cunha CA, Farnham PJ. Direct recruitment of N-myc to target gene promoters[J].Mol Carcinog, 2000,29(2):76-86.
2Xu D, Wang Q, Gruber A, et al, Down-regulation of telomerase reverse transciptase mRNA expression by wild type p53 in human tumor cell[J].Oncogene, 2000, 19(45) :5123-5133.
3Jones PA, Laird PW. Cancer epigenetics comes of age[J]. Nat genet, 1999,21 (2) : 163-167.
4Baylin SB, herman JG. DNA hypermethylation in tumorigenesis,epigenetics joins genetics[J]. Trends genet, 2000, 16 (4) :168-174.
