96例神经系统疾病患者脑脊液中乳酸脱氢酶及其同功酶的测定

Determination of cerebrospinal fluid lactic dehydrogenase and its isozymes in 96 patients with neurological disorders

我们两年来测定了脑脊液(CSF)中乳酸脫氢酶(LDH)及其同功酶作为诊断和鉴别诊断某些神经系统疾病的一种辅助方法。本文报道96例神经系统疾病患者测定CSF—LDH及其同功酶的初步结果。材料与方法 1.测定对象:自1982年1月至1983年12月测定了96例(男60;女36)因神经系统疾病住我院神经内科的患者。年龄13～87岁,平均43.48岁。疾病种类为急性脑血管病28例、中枢神经系统(CNS)感染16例、CNS变性(如脊髓小脑变性、运动神经元疾病等)ll例,CNS肿瘤9例、癫痫4例、周围神经病(如三叉神经痛、周围神经炎等)8例,肌病4例,其它神经系统疾病(如血管性头痛、神经衰弱、颈椎病等)16例。住院后首次作腰穿(无外伤)

The total activity of CSF lactic dehydrogenase (CSF-LDH) and its isozymes in 96 patients with neurological disorders were measured and analysed clinically.Thirty-two general surgical cases without neurological disorders Were used as controls.The results showed that the total activity of CSF-LDH was normal in 73 patients,increased in 1l patients,and decreased in 12 patients (O in 7 patients ).The isozyme pattern of CNSLDH was abnormal in 27 patients.The changes of the isozyme pattern of CSF-LDH were discussed in the CNS infections and cerebrovascular diseases.The determination of CSF-LDH and its isozymes in the neurological disorders can afford only a reference value for the diagnosis.