摘要
下腰痛是骨科常见的疾病之一,而椎间盘髓核退变是引起下腰痛的主要原因。目前对于椎间盘退变的治疗方式主要是保守治疗和手术治疗,然而这些治疗方法的目的是缓解症状,并非是针对椎间盘退变发生机制的病因治疗。对椎间盘髓核退变发生机制的详细了解有助于开展生物学再生修复。目前,针对髓核退变的分子机制和背景,发展出不同的髓核退变生物学再生修复的方法。文章从生长因子治疗、基因治疗、细胞治疗、组织工程化髓核等方面对髓核退变生物学再生修复进行综述。
Low back pain is one of common diseases of orthopedics,and the degeneration of intervertebral disc is the main cause of lower back pain.Currently,the treatment of disc degeneration mainly contains conservative treatment and surgical treatment.However,both treatment methods can only alleviate the patient’s pain and decrease the patient’s symptoms,which cannot fundamentally solve the problem of disc degeneration.Therefore,understanding the mechanism of nucleus pulposus degeneration can help us to develop biological regeneration and repair.At present,different regeneration and repair methods of nucleus pulposus degeneration have been developed based on the mechanism of nucleus pulposus degeneration.This article reviews the latest strategies for nucleus pulposus regeneration,including growth factor therapy,gene therapy,cell therapy,and tissue engineering reconstruction.
作者
陈铭
沈军
Chen Ming;Shen Jun(Department of Orthopeadic Surgery,the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Suzhou 215002,China)
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2019年第5期774-780,共7页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省自然科学基金(BK20151196)
江苏省第5期"333工程"科研项目(BRA2017057)
关键词
椎间盘退变
生长因子治疗
细胞治疗
基因治疗
组织工程治疗
intervertebral disc degeneration
growth factor therapy
cell therapy
gene therapy
tissue engineering
