摘要
传统观点认为睾酮治疗会促进前列腺癌细胞的生长,所以睾酮治疗不适用于前列腺癌患者,但是最近越来越多的临床研究结果与这一传统认识相悖。目前研究表明,高内源性雄激素水平不增加前列腺癌的发病风险,也不促进前列腺癌患者的疾病进展。雄激素受体的饱和似乎可以解释这种现象;并且对于睾酮缺乏(testosterone deficiency,TD)的前列腺癌患者,睾酮治疗可以改善其生活质量。睾酮在前列腺癌生长和治疗中的作用十分复杂,还需要进一步探索。因此,本文就睾酮与前列腺癌关系的最新研究作一综述。
Traditionally,testosterone therapy can promote the growth of prostate cancer cells,so testosterone therapy is not suitable for prostate cancer patients,but the results of recent researches are contrary to the axiom.The current research indicates that the high endogenous androgen levels do not increase the incidence of prostate cancer and do not contribute to disease progression in prostate cancer patients.Androgen saturation model seems to explain this phenomenon;and for the prostate cancer patients with testosterone deficiency(TD),testosterone therapy can improve the quality of life.The role of testosterone on the growth and treatment of prostate cancer is complex,and further exploration is needed.Therefore,this article reviews the recent research on the relationship between testosterone and prostate cancer.
作者
江杰
梁超
苗陈岿
王增军
邵鹏飞
Jiang Jie;Liang Chao;Miao Chenkui;Wang Zengjun;Shao Pengfei(Department of Urology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2019年第9期1399-1402,共4页
Journal of Nanjing Medical University(Natural Sciences)
关键词
睾酮
饱和模型
睾酮缺乏症
前列腺癌
testosterone
saturation model
testosterone deficiency
prostate cancer
