金线莲液治疗儿童白血病化疗后口腔溃疡的临床研究

Clinical Study of Anoectochilus Roxburghii Liquid in Treating Oral Ulcer Due to Chemotherapy for Childhood Leukemia

目的观察金线莲液对儿童白血病化疗后出现口腔溃疡的临床疗效。方法将符合标准的儿童白血病化疗后出现口腔溃疡76例患儿随机分为开喉剑组40例(对照组)和金线莲液组36例(试验组),比较2组患者经过不同方案治疗前后口腔黏膜破溃分度情况、口腔溃疡疼痛评分以及总体临床疗效。结果试验组在缩小口腔溃疡面积、缓解疼痛方面较对照组效果明显(P<0.05),口腔溃疡分级情况比对照组口腔溃疡分级愈合情况更好(P<0.01),临床疗效优于对照组(P<0.05)。2组患者在治疗过程中均无明显不良反应。结论金线莲液治疗儿童白血病化疗后出现的口腔溃疡临床效果明显优于开喉剑喷雾剂。

OBJECTIVE To observe the clinical effects of Anoectochilus Roxburghii liquid in treating oral ulcer due to chemotherapy for childhood leukemia.METHODS 76 children with oral ulcer due to chemotherapy for childhood leukemia were randomly divided into control group(40cases)treated with Kaijiankou Sprayer and treatment group(36cases)treated with Anoectochilus Roxburghii liquid.Mouth ulceration and its pain degree of both groups were compared before and after treatment together with the total clinical effects.RESULTS The treatment group possessed evident advantages over the control group in improving oral ulcerative areas(P<0.05).The treatment group was superior in relieving the pain to the control group(P<0.05).And the ulcer classification of the treatment group was better than that of the control group(P<0.05).No evident side effects were detected in the two groups.CONCULSION Anoectochilus Roxburghii liquid has better clinical effects than Kaijiankou sprayer in treating oral ulcer due to chemotherapy for childhood leukemia,which deserves wide clinical application and promotion.