血栓弹力图评测三七皂苷联合阿司匹林对老年冠心病患者抗栓疗效的影响

Influence of Panax Notoginseng Saponins Combined with Aspirin on Senile Coronary Heart Disease by Thromboela-stogram

目的通过血栓弹力图(TEG)观察三七皂苷联合阿司匹林的抗栓疗效。方法将51例老年冠心病患者随机分为对照组和试验组,对照组口服拜阿司匹林,试验组口服三七通舒胶囊和拜阿司匹林,观察2组对TEG和花生四烯酸诱导途径血小板抑制率(AA%)的影响。结果 2组间对照显示试验组在提高R值、K值及Angle角方面有统计学差异(P<0.05~0.01)。结论三七皂苷联合阿司匹林在抗栓方面优于单用阿司匹林,且不增加不良反应。

OBJECTIVE To observe antithrombotic effects of panax notoginseng saponins plus aspirin via applying thromboela-stogram(TEG).METHODS 51 patients with senile coronary heart disease were randomly divided into treatment group and control group,with patients in the control group being given aspirin while whose in the treatment group being treated with Sanqi Tongshu Capsule and aspirin.TEG of both groups were observed together with platelet inhibition rate(AA%)induced by arachidonic acid.There existed a statistical significance between the two groups in improving R value,K value and alpha Angle(P<0.05~0.01).RESULTS Reducing scores on SDRS and HAMA of the treatment group before and after treatment were evidently higher than those of the control group(P<0.01).Both groups were effective in improving PSG parameters including sleeping time,sleep latency and sleep efficiency after treatment(P<0.05),but the treatment group was superior to the control group(P<0.05).The total curative rate of treatment group and control group were 84.85% and 67.74% respectively with a statistical significance between the two groups(P<0.05).CONCULSION Panax notoginseng saponins plus aspirin is superior to aspirin in anti-thrombosis,without increasing the side effects.