矿物药青礞石干预COPD大鼠模型的多层数据分析

Multi-Layer Analysis of Chloriti Lapis on Rats Model with COPD

目的分析矿物药青礞石治疗慢性阻塞性肺疾病(COPD)大鼠的疗效。方法建立COPD大鼠模型,结合青礞石临床应用的方法及剂量,分别给予青礞石粉高剂量、低剂量,水煎液高剂量、低剂量,药渣高剂量、低剂量加以治疗,检测大鼠肺组织、血清中炎症因子的含量。运用典型相关分析、主成分分析、线性多层统计模型评价相关指标。结果水煎液高剂量组效果最好,粉末高剂量组次之,渣高剂量组第三。结论青礞石能有效降低COPD模型大鼠血清及肺组织中炎症因子的水平,通过典型相关分析、主成分分析、线性多层数据模型可区分不同处理方法的疗效差异。

OBJECTIVE To study the curative effects of Chloriti Lapis on rats with chronic obstructive pulmonary diseases(COPD).METHODS Rats models of COPD were established and were given the powder,decoction and residues of Chloriti Lapis of both high dosage and low dosage respectively based on its clinical application methods and dosage.Inflammatory factor content in rats lung tissue and blood serum was tested and relative indexes were evaluated through canonical correlation analysis,principal component analysis and multiple linear statistical models.RESULTS The high dosage group of decoction reached the best result,with the high dosage group of powder being the second and the high dosage group of residues being the third.CONCULSION Chloriti Lapis is effective in reducing inflammatory factors of both blood serum and lung tissue of rats models with COPD.The curative effect differences due to processing methods can be detected by canonical correlation analysis,principal component analysis and multiple linear statistical models.