呼气试验数值对幽门螺杆菌根除率影响研究

The influence of 13C-urea breath test result values on Helicobacter pylori eradication

目的 :探讨呼气试验数值对幽门螺杆菌(Helicobacter pylori,Hp)根除率的影响。方法 :通过前瞻性研究,根据碳13呼气试验(13C-urea breath test, 13C-UBT)阳性的数值,将患者分成低、中和高3组,分别给予不同的2种四联抗菌治疗14 d。停药8周,复查13C-UBT,分析3组的Hp根除率有无差异,13C-UBT数值高低与根除率是否相关。结果:阿莫西林+克拉霉素组低、中、高3组的Hp根除率分别为94.1%、94.9%和87.5%,Kendall相关系数R=-0.043 4,P=0.207 5。阿莫西林+左氧氟沙星组低、中、高3组的Hp根除率分别为92.0%、93.3%和88.9%,Kendall相关系数R=-0.091 4,P=0.688。2种不同方案的根除治疗3组间根除率比较差异无统计学意义(P>0.05)。且呼气试验数值高低与根除率即治疗的疗效无相关性(P>0.05)。结论:呼气试验的数值对Hp根治率无影响。2种四联抗Hp治疗对不同数值的感染者根除率都达到可接受水平。

Objective To study the influence of 13C-urea breath test(13C-UBT)results values on Helicobacter pylori(Hp)eradication.Methods Individuals with positive 13C-UBT test were enrolled in the study and divided into three groups(low,medium,high)according to the degree of13C-UBT.Two standard quadruple eradication regimen were given for 14 d.Eight weeks after the therapy,13C-UBT was performed to evaluate the eradication rate.Results The eradication rates achieved with amoxicillin and clarithromycin regimen were 94.1%,94.9%and 87.5%among patients with low,medium,high positive results of13C-UBT(Kendall’s tau R=-0.043 4,P=0.207 5).The eradication rates of amoxicillin and levofloxacin regimen were 92.0%,93.3%and 88.9%in the three groups respectively(Kendall’s tau R=-0.091 4,P=0.688).Neither of the treatment regimen showed statistical difference in eradication rates regarding the positivity of the results(P>0.05).Conclusions The result value of13C-UBT test has no influence on the eradication rate of two quardruple treatment regimens.