摘要
Sonic hedgehog(Shh)是维持男性勃起功能的重要调节因子,异常的Shh信号可能是导致ED的机制之一。目前关于Shh信号通路与ED的研究主要集中在双侧海绵体神经损伤的神经源性ED,糖尿病导致的内分泌性ED以及老年性ED。本文梳理了不同类型ED中Shh信号通路的改变,阐明了Shh信号通路在ED中的调控机制,以期对今后的相关研究给予启发。
Sonic hedgehog(Shh)is an important regulator of penile erectile function in adult males,and abnormal Shh signals may be involved in the mechanisms of ED.Current studies on the relationship of the Shh signaling pathway with ED are mainly concentrated on neurogenic ED caused by bilateral cavernous nerve injury,diabetes-induced endocrinological ED,and senile ED.This review focuses on the changes of the Shh signaling pathway in different types of ED and clarifies the mechanisms of the Shh signaling pathway regulating ED,hoping to give some inspiration to further related studies.
作者
马轲(综述)
叶妙勇(综述)
赵凡(综述)
吕伯东(审校)
MA Ke;YE Miao-yong;ZHAO Fan;LüBo-dong(The Second School of Clinical Medicine,Zhejiang University of Chinese Medicine,Hangzhou,Zhejiang 310053,China;Department of Urology and Andrology,The Affiliated Hospital of Nantong University,Nantong,Jiangsu 226001,China;Department of Urology and Andrology,The Second Affiliated Hospital of Zhejiang University of Chinese Medicine,Hangzhou,Zhejiang 310005,China;Key Laboratory of Zhejiang Province for Traditional Chinese Medicine(Andrology),Hangzhou,Zhejiang 310053,China;Research Institute of Urology and Andrology,Zhejiang University of Chinese Medicine,Hangzhou,Zhejiang 310005,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2019年第9期833-837,共5页
National Journal of Andrology
基金
国家自然科学基金(81571431
81603620)
浙江省自然科学基金(LY18H270002
LQ19H040001
LY19H270011)
浙江省中医药重大研究项目(2018ZY007)~~
