泰地罗新单次口灌给药与连续饮水给药后在猪体内的药动学比较研究

THE COMPARATIVE STUDIES OF PHARMACOKINETICS OF TILDIPIROSIN IN PIG(SINGLE ORAL ADMINISTRATION AND CONTINUOUS DRINKING WATER ADMINISTRATION)

为了探究泰地罗新在猪体内瞬时和连续给药条件下药物动力学的差异,本试验通过给猪瞬时给药(单次口服)和连续给药(饮水添加给药)来探究药动学参数的差异;试验结果表明泰地罗新单次给药后在猪血浆中的消除较慢,给药240h后仍可在血浆中检测到,连续饮水添加给药刚开始符合有吸收一室模型,与单次给药一致。泰地罗新在猪体内吸收快,消除半衰期长,瞬时给药可长时间维持较高的血药浓度,而小剂量连续(饮水添加)给药,也可在短时间内达到稳态浓度;所以说泰地罗新在临床使用过程中瞬时给药和连续给药均能达到治疗疾病的目的。

The difference of Pharmacokinetics of Tidipirosin in pig after oral administration between instantaneous and continuous input would be discussed;The pharmacokinetic parameters of tildipirosin in pigs were studied comparatively in this experiment following by given instantaneous( single oral) and continuous( Drinking water added to medicine). These results revealed that the elimination of tidiloxine in pig plasma was slow after single administration,and it can still be detected in plasma after 240 h of administration.The continuous drinking water addition was initially consistent with the absorptive one-chamber model,which was consistent with single administration. Tidipirosin was absorbed quickly and eliminated slowly in pigs,so the instantaneous input can maintain a high blood concentration for a long time,However,a small dose of continuous( drinking water added) can also achieve steady state concentration in a short period of time. Therefore,Tidipirosin can achieve the aim of treating diseases with instantaneous and continuous administration in clinic use.